Managing complexity has a long tradition for algorithms and general problems. However, it is an important issue also in Business Informatics domain. Here the complexity of different systems and systems of systems has to be managed. While complexity usually associates with large or very large scale systems still managing complexity is important even for systems with small sizes operating in complex environment. Nowadays informatics requires handling complexity at different levels and configurations of social, physical, enterprise, software, and hardware systems. The workshop is planned to focus on approaches and methods for managing complexity in the domain of applied informatics that may concern interplay of systems and ecosystems of various sizes and substances. Its purpose is to share and transfer knowledge on complexity identification, representation, controlling and reduction as well as to exploit possible synergies in development of innovative complexity handling strategies, a pproaches, and methods.